Preclinical skin tolerability tests are essential for assessing the safety of new drugs, cosmetics, or topical formulations before human use. They help identify potential irritation, sensitization, or adverse skin reactions, ensuring products are well-tolerated.
Skin Tolerability - Methodology
Species: rats, pig
Subcutaneous injections
Timeline: in-life phase 4 weeks, total 7 weeks
Skin Tolerability - Readouts & Application
Readouts:
Macro- and microscopic evaluation
Markers of inflammation
Application:
This early evaluation supports regulatory compliance, guides formulation improvements, and increases the likelihood of safe and effective clinical outcomes.
