Readouts:

• Systemic Arterial Pressure (dias SAP, Syst SAP, mSAP)

• Pulmonary Arterial Presure (dias PAP, systPAP, mPAP)

• Fulton’s Index / RVFW

• Echocardiography; SV, CO, Vmax, PAAT Vti

• Histology (morphometric analysis)

Application:

• This PAB model provides a unique setting to study the effects of RV pressure overload that is consistent in severity and is a purely mechanical insult, which is free of injury to the pulmonary or systemic vasculature