Bile duct ligation (BDL) surgery is one of the extensively utilized experimental models for studying liver fibrosis. The cholestatic liver injury induced by ligation leads to apoptosis in bile duct cells and elicits a fibrotic response.
Bile Duct Ligation - Methodology
Species: rats
Bile duct ligation surgery
Timeline: in-life phase 3 weeks, total 6 weeks
Bile Duct Ligation - Readouts & Application
Readouts:
Histology: H&E, PSR
Fibrosis scoring (Ishak scale)
Blood chemistry, ALT, AST, Bilirubine
Portal venous pressure
Application:
The BDL model induces liver fibrosis under controlled conditions with a significant advantage, it shortens the research timeframe. It is designed for evaluating the efficacy of test articles in preventing or treating liver fibrosis.
