Chronic wounds, such as diabetic ulcers and pressure sores, are a significant clinical challenge due to prolonged healing and infection risk. Current treatments are often insufficient, creating a need for new therapies to improve healing and reduce complications.
Wound Healing - Methodology
Species: rats, pigs
Punch biopsy and healing assessment
Timeline: in-life phase 3 weeks, 6 weeks total
Wound Healing - Readouts & Application
Readouts:
Macroscopic wound closure assessment
Histology, H&E, Masson Trichrome
Wound healing score
Growth factors and cytokines
Application:
The wound healing model is a preclinical tool to evaluate therapeutic agents for tissue repair. It closely replicates human wound healing, allowing assessment of treatment effects on wound closure, scarring, and tissue regeneration.
