Aortic valve stenosis is a progressive cardiovascular disease characterized by narrowing of the aortic valve, which obstructs blood flow from the left ventricle to the aorta. The condition leads to pressure overload, left ventricular hypertrophy, and eventually heart failure.
Aortic Valve Stenosis - Methodology
Species: Rat
Surgically-induced aortic valve stenosis under echocardiographic guidance
Timeline: in-life phase up to 10 weeks, total 14 weeks
Aortic Valve Stenosis - Readouts & Application
Readouts:
Echocardiography
PV loops
Histology
Application:
Preclinical models of AVS are crucial for mimicking this pathophysiology, allowing researchers to evaluate potential therapeutic interventions before clinical translation.
