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DOCA-Salt Hypertension Model of Diastolic Dysfunction
The DOCA-salt model is a hypertension-driven model used to study cardiac remodeling, vascular dysfunction, renal injury, fibrosis, and diastolic dysfunction.
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Following uninephrectomy, deoxycorticosterone acetate administration, and high-salt diet, animals develop sustained hypertension with cardiovascular and renal target-organ effects.
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IPS Therapeutique uses this model to evaluate therapies targeting hypertension, cardiac stiffness, diastolic dysfunction, fibrosis, renal injury, and HFpEF-relevant pathophysiology.
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