Sepsis remains a major global health challenge, associated with high mortality and long-term complications. The hallmarks of sepsis are systemic inflammation, immune dysregulation, and multi-organ dysfunction.
Sepsis - Methodology
Species: rats, mice
Cecal ligation and puncture
Timeline: in-life phase 24-72h, total 3 weeks
Sepsis - Readouts & Application
Readouts:
Plethysmography
Cardiovascular function
Cell count and cytokines
Survival curve
Application:
This model reproduces the acute hyperinflammatory response as well as the later immunosuppressive phase, allowing the study of both early and late pathological mechanisms.
