Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome that is becoming more prevalent. It is linked to a diminished quality of life and premature mortality. There is currently no effective treatment for HFpEF.
“Two-Hit” Model of HFpEF - Methodology
Species: mice, rats
High fat diet, L-NAME supplied in drinking water
Timeline: in-life phase 12 weeks, total 15 weeks
HFpEF - Readouts & Application
Readouts:
Echocardiography
PV loop
Histology: H&E, PSR
Exercise tolerance
Application:
The model replicates several aspects of human pathology, such as metabolic and cardiac function alterations. It is intended to assess efficacy of new drug candidates.
