Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by a temporary or prolonged reduction in circulating platelet levels, with no other underlying conditions identified to cause thrombocytopenia.
Immune Thrombocytopenia - Methodology
Female C5BL/6 mice of 7-8 weeks are injected with anti-CD41 antibody leading to rapid onset of ITP.
Immune Thrombocytopenia - Readouts & Application
Readouts:
Platelet counts
Bleeding time
Application:
This model based on the passive transfer of antiplatelet antibodies is perfectly suited to assess efficacy of treatment against immune thrombocytopenia.
