Hemorrhagic shock is the leading cause of mortality in trauma patients. It consists of decreased tissue perfusion, hypoxia, metabolic damage and immune. Current medicine lacks an effective approach to treat this condition.
Acute Hemorrhagic Shock - Methodology
Species: rats
Intermittent withdrawing of blood
Timeline: in-life phase 1 day, total 3 weeks
Acute Hemorrhagic Shock - Readouts & Application
Readouts:
Survival rate
Respiration rate, oxygen saturation
Blood pressure, heart rate
Blood biochemistry and cytokines
Application:
The model enables the assessment of whether test articles improve survival in acute hemorrhagic shock.
