Introducing our newly developed model for studying idiopathic pulmonary fibrosis, which employs a different methodology, and shows advanced alterations in pulmonary physiology and morphology.
Next-Gen IPF - Methodology
Species: rats, mice
Bleomycin, two oropharyngeal aspirations
Timeline: in-life phase 4 weeks, total 7 weeks
Next-Gen IPF - Readouts & Application
Readouts:
Plethysmography
Pulmonary PV loop analysis
Lung histology with Ashcroft score
Morphometric analysis
Collagen and hydroxyproline concentrations
Application:
Assess the drug candidate's efficacy in slowing or reversing the progression of IPF
