This model is frequently used to study adverse cardiac remodeling upon pressure overload.
Species: rat, mice
Partial ligation of the aortic arch between 1st and 2nd or 2nd and 3rd branches.
Timeline: in-life phase 6-8 weeks, total 11 weeks
Readouts:
Systemic Arterial Pressure (dias SAP, Syst SAP, mSAP)
Fulton’s Index / RVFWT
Echocardiography; LVESV, LVEDP, LVEDD, LVESD, EF, FS
Histology (morphometric analysis)
Application:
This transverse aortic constriction model offers a distinctive setting for investigating the impacts of left ventricular pressure overload. It is designed to study the mechanisms behind cardiac hypertrophy, fibrosis and eventually cardiac dilation.
