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SuHx-Induced PAH Rat Model
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Pulmonary arterial hypertension (PAH) is a progressive debilitating disease characterized by increase pulmonary arterial pressure leading to right ventricular failure. The Sugen5416 (Su), an inhibitor of VEGF receptor known to damage the endothelial cell which, when combine with hypoxia (Hx), induces PAH in rodent with formation of plexiform arteriopathy that resembles the histology in human PAH of type 1.
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