Hypertrophic cardiomyopathy (HCM) is a genetic disorder characterized by the thickening of the heart muscle, particularly the left ventricle, that results in impaired blood flow.
Species: rats
Injection of isoproterenol (ISO), daily
Timeline: in-life phase 3 weeks, total 6 weeks
Readouts:
Echocardiography
PV loop
Histology; H&E, PSR
Cytokines
Application:
The HCM model is intended to assess efficacy of a new drug candidate's in:
Improving cardiac function
Preventing/reversing cardiac hypertrophy
