This model seeks to offer a methodological foundation for future therapies addressing chronic cough and facilitating pharmacological research on drugs designed for its treatment.
Chronic Cough - Methodology
Species: guinea pigs
Repeated inhalation of citric acid or Capsaicin-induced cough
Timeline: in-life phase 3 weeks, total 6 weeks
Chronic Cough - Readouts & Application
Readouts:
Number of coughs
Plethysmography
BALF cell count
Histology, H&E
Application:
This model is exceptionally well-suited for evaluating antitussive drugs targeting chronic cough. It specifically assesses alterations in the plasticity of afferent vagus nerve C-fibers and their receptors, which play a pivotal role in cough hypersensitivity.
