Breathing low level of oxygen reduces the oxygen in the blood which increase pulmonary arterial (PA) vascular tone. The acute PA tone response to hypoxia does not involve remodeling and can be use to rapidly assess vasodilator molecules effect.
Hypoxia-Induced Acute PAH - Methodology
Species: anesthetized rats
Ventilated with reduced oxygen-induced PAH
systemic and pulmonary pressures monitored for up to 120 min
