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Learn how to choose endpoints for preclinical efficacy evaluation. Aligning functional, structural, and molecular readouts strengthens interpretation.

Discover the role of preclinical efficacy studies in early drug discovery. Learn how study design, endpoints, and interpretation shape program advancement.

Explore where translational gaps emerge in cardiometabolic drug programs. Learn how model choice, endpoints, and dosing shape clinical predictivity.

Learn the common study design challenges in preclinical development. Address model selection, sample size, endpoints, and controls before study initiation.

Learn how peer-reviewed evidence reveals a CRO disease model validation, endpoint sensitivity, and scientific expertise.

Learn what scientific direction delivers in a preclinical CRO partnership. Study design collaboration shapes better data and faster development decisions.

Connect in vivo efficacy data to Seahorse metabolism, flow cytometry, and omics readouts. Learn how integrated preclinical studies build mechanistic evidence.

Compare venous stasis and FeCl3 arterial thrombosis models for preclinical drug development. Learn when to use each and how to interpret readouts.

Fibrosis is a cross-organ disease involving lung, liver, and kidney injury. Align models and endpoints to improve translational relevance.

Respiratory disease models need functional readouts that translate. Match ARDS, COPD, and IPF models to biology and mechanism.

In vitro proarrhythmic liability is more predictive when paired with in vivo telemetry. Integrated testing improves cardiac safety decisions early.

Pulmonary hypertension models must match PAH or CTEPH biology. The right choice improves hemodynamics, remodeling data, and translational value.

Metabolic heart failure involves mitochondrial dysfunction and systemic disease. Learn what preclinical models can and can’t reveal.

HFpEF and HFrEF need different preclinical models and endpoints. Learn how model selection and induction methods improve translational relevance.

GLP changes study design, QA, and documentation in preclinical research. Learn what shifts from non-GLP to regulated studies.

In vivo disease models help reduce late-stage drug development risk. The right translational choice improves relevance, biomarkers, and confidence.

On April 14, Harvard University saw 2.2 billion US$ in grant money frozen after it elected to maintain diversity, equity and inclusion policies. Princeton, Cornell, Northwestern universities also suffered cuts in funding for similar reasons. As the freezing of research funding expands weekly in the US, universities have created “bridge funding” to support affected graduate students and programs. Furthermore, alternative sources of cash are under consideration: after all, weal

The inexorable drive for success when most basic needs have been fulfilled propels inventors in amusing places indeed: today, the FAA released its guidance on the use of electrical air taxis - à la Jetsons... It takes a special brain to innovate. A precious ability to disregard everything you know, think outside the box, and look at an issue with new eyes. It requires throwing away the existing confines, and re-inventing with a new direction. I can’t do that: I’ve been calle

Last week at the local tailor shop, I was presented with the ecological argument to purchase a custom-made shirt: “The fit is impeccable, and instead of making 3 shirt sizes (Small, Medium, Large) to sort-of fit your body, a single shirt will be made. Less time, less energy, less waste.” I’m a common 16.5-32 slim-fit-shirt guy, so I walked out without the $150 tailored shirt, but with a useful analogy… My team specializes in custom-designed preclinical studies. “Bespoke”, “Un

I was reminded last week of the extraordinary circumstances which allow scientists to pursue a life’s passion – the generation of new knowledge, in all fields of research; Aside from talent and interest -thanks for the genes, Mom & Dad!-, the location of our birth and upbringing, the patience and devotion of our teachers, and a fair chunk of cash led us all to the labs where we labor today. In addition to parental support, the public’s financial contribution to the education