Are your most potent compounds safe?
The assays included therein are designed to be predictive, robust, and economical.
In selecting the number of tissues, concentrations, and parameters evaluated, particular consideration has been given to maintaining a high statistical power, therefore maximizing the reliability of the results generated.
In addition, the assays are also meant to provide a rapid quantitative assessment of the cardiac liability associated with each of a large number of compounds. In essence, the Safe Lead Select assays represent scaled down versions of the full-size, functional assays being performed prior to IND submission, for a fraction of the price.