Acute hypoxia-induced pulmonary arterial hypertension (PAH)

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Acute hypoxia was first developed to mimic and study the pathology of persistent pulmonary hypertension of the newborn PPHN. The rapid pulmonary vessel constriction response to the hypoxic stimulus without tissue remodeling allows us to monitor and observe the rapid effect of antihypertensive agents such as nitric oxide (see figure below) on pulmonary arterial pressure.