Metabolic profiles

  • Cell-based assays are a powerful tool for drug efficacy discovery. IPST‘s cardiometabolic lab offers some interesting endpoints including substrates metabolism (glucose and lipid uptake) in adipose, muscular, hepatocyte and cardiomyocyte cells.
    • Respiratory capacity (a surrogate for energetic status)
      • cell oxygen consumption
      • cell C02 production
      • cell respiratory exchange ratio

 

  • In vivo-based assays provide powerful efficacy models to evaluate test articles on different metabolic diseases – with a focus on exercise activity, metabolic disorders associated with obesity, and type 2 diabetes, i.e., dyslipidemia, atherosclerosis, hepatic steatosis, adipose tissue remodelling, cardiomyopathy and insulin resistance.
    • Exercise
    • Obesity
    • Diabetes

 

  • In vivo heart rate and body temperature recording. Metabolic abnormalities have been linked to hormonal and substrates changes in the blood. Such modifications have a direct impact on cardiac functionalities. IPST‘s cardiometabolic lab offers heart rate monitoring over prolonged periods of time to evaluate the effect of test articles on cardiac function.
    • Body temperature has been linked to many changes in terms of energy expenditure and heart function. A lower body temperature will be associated with an increase in shivering and non-shivering thermogenesis which will increase the energy expenditure. On the other hand, a higher body temperature will decrease the basal metabolic rate and increase weight gain.
    • IPST offers microchip implantation to record heart rate and body temperature during the full length of the study. These recording chips are compatible with a wide range of customized study models.